Process of optically resoluting optically active platinum comple

Details Process of optically resoluting optically active platinum comple Process of optically resoluting optically active platinum comple

1993-04-07

1994-03-29

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 1500

Patent

active

052986420

ABSTRACT:
Disclosed herein is a process of optically resoluting optically active platinum complex compounds which comprises optically resoluting a d-isomer and an 1-isomer of a cis-Pt(II) complex of a 1,2-cyclohexanediamine isomer characterized in that the mixture of the d-isomer and the 1-isomer is optically resoluted by means of high performance liquid chromatography employing a column packed with a chiral filler.
The chiral filler include, for example, a cellulose ester derivative, a cellulose carbamate derivative, an amylose carbamate derivative, a polymethacryl acid ester and .beta.- and .gamma.-cyclodextrin.
According to the present invention, the optical resolution of a platinum complex compound essentially consisting of the mixture of two optical isomers which cannot be resoluted in accordance with a normal resolution method due to the small structural difference can be easily performed utilizing the characteristics of a chiral filler.

REFERENCES:
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patent: 4921984 (1990-05-01), Nowatari et al.
patent: 5068376 (1991-11-01), Nowatari et al.
patent: 5128493 (1992-07-01), Nowatari et al.

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