Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Reexamination Certificate
2000-05-15
2002-08-20
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
C424S400000, C424S076210, C514S937000
Reexamination Certificate
active
06436442
ABSTRACT:
TECHNICAL FIELD
The present invention relates to processes of manufacturing stable compositions comprising functionally-available cyclodextrin and cyclodextrin-incompatible material. The stable compositions can be used for capturing unwanted molecules in a variety of contexts, preferably to control malodor including controlling malodorous molecules on inanimate surfaces, such as fabrics, including carpets, and hard surfaces including countertops, dishes, floors, garbage cans, ceilings, walls, carpet padding, air filters, and the like, and animate surfaces, such as skin and hair.
BACKGROUND OF THE INVENTION
Cyclodextrin is known to form complexes with certain materials. In many compositions, cyclodextrin is used as a carrier for active materials and thus it is desirable to form complexes between cyclodextrin and the active materials in order for the cyclodextrin to act as a carrier for the active materials. This is especially prevalent in the pharmaceautical area, where cyclodextrins have been traditionally used as carriers to deliver active materials. However, when cyclodextrin is used as a carrier for active material and is strongly complexed with the active material, the cavities of the cyclodextrin molecules are filled such that the cyclodextrin is not available to complex with other molecules.
Surfaces, especially household surfaces such as fabrics, countertops, and the like, often contain unwanted molecules, such as malodorous molecules. Cyclodextrin molecules are capable of capturing unwanted molecules from surfaces; however, cyclodextrin compositions used to treat surfaces containing unwanted molecules must have cyclodextrin that is available to complex with the unwanted molecules in order to capture and remove the unwanted molecules from the surface being treated. Compositions have been disclosed that are useful for controlling malodor on surfaces, wherein the compositions comprise uncomplexed cyclodextrin. For example, U.S. Pat. No. 5,942,217 issued Aug. 24, 1999 to Trinh et al. teach compositions for controlling malodor on surfaces wherein the compositions can comprise uncomplexed cyclodextrin and materials that are cyclodextrin-compatible, such as cyclodextrin-compatible surfactants and cyclodextrin-compatible antimicrobial actives. The materials in these compositions are selected such that they do not complex with cyclodextrin in solution, thus providing available, uncomplexed cyclodextrin in solution to capture the malodor from the treated surfaces.
However, this has resulted in only a limited range of materials being suitable for addition to cyclodextrin-containing compositions of this type. Certain materials are desirable as components but have hitherto generally not been added due to their incompatibility with cyclodextrin.
It has thus been desired to develop processes of manufacturing a composition comprising cyclodextrin-incompatible material and cyclodextrin, such that the cyclodextrin is functionally-available to capture unwanted molecules from treated surfaces.
SUMMARY OF THE INVENTION
The present invention relates to processes of manufacturing compositions for capturing unwanted molecules from inanimate surfaces, including fabrics, including carpets, and household surfaces such as countertops, dishes, floors, garbage cans, ceilings, walls, carpet padding, air filters, and the like, and from animate surfaces, including skin, hair, and the like. The compositions herein for capturing unwanted molecules comprise cyclodextrin and cyclodextrin-incompatible material. The compositions can further comprise cyclodextrin-compatible materials and other optional ingredients.
The present process of manufacturing a composition suitable for capturing unwanted molecules comprises the steps of:
(a) providing cyclodextrin, a cyclodextrin-compatible material, and a cyclodextrin-incompatible material;
(b) combining said cyclodextrin-compatible material and said cyclodextrin-incompatible material to form a first mixture; and
(c) subsequently combining said cyclodextrin with said first mixture to form said composition suitable for capturing unwanted molecules.
The processes can also comprise combining the cyclodextrin-compatible material and the cyclodextrin-incompatible material with water to form a first aqueous mixture and subsequently adding cyclodextrin to the first aqueous mixture to form the composition suitable for capturing unwanted molecules. The present processes can also comprise combining the cyclodextrin-compatible material and the cyclodextrin-incompatible material to form a first mixture, combining the cyclodextrin with water to form a second aqueous mixture and combining the first mixture and the second aqueous mixture to form the composition suitable for capturing unwanted molecules.
It is particularly preferred to use a cyclodextrin-compatible surfactant as the cyclodextrin-compatible material in the present processes. Such cyclodextrin-compatible surfactant materials are believed to form molecular aggregates such as micelles or vesicles which encapsulate the cyclodextrin-incompatible material and prevent it from interacting with the cyclodextrin. This allows incorporation of desirable, but cyclodextrin-incompatible, materials by preventing their interaction with the cyclodextrin in the compositions.
DETAILED DESCRIPTION OF THE INVENTION
I. Compositions
The present invention encompasses stable compositions comprising functionally-available cyclodextrin and cyclodextrin-incompatible material. The cyclodextrin-incompatible materials can be cyclodextrin-incompatible surfactants, cyclodextrin-incompatible perfume materials, cyclodextrin-incompatible skin conditioning agents, and the like. The compositions can further comprise cyclodextrin-compatible materials, such as cyclodextrin-compatible surfactant and other optional components.
The present compositions can be either emulsions/dispersions or clear, single-phase solutions. Compositions of the present invention for controlling malodor on fabrics are preferably clear, single-phase solutions and generally have a particle size of molecular aggregates, such as micelles and/or vesicles, of no greater than about 0.2 &mgr;m, preferably no greater than about 0.1 &mgr;m, and more preferably no greater than about 0.05 &mgr;m. Preferably, the cyclodextrin compositions of the present invention are clear. The term “clear” as defined herein means transparent or translucent, preferably transparent, as in “water clear,” and have a percent transmittance of at least about 70%, preferably at least about 75%, and more preferably at least about 80% at 420 nm.
Compositions of the present invention such as detergent compositions, fabric softening compositions, shampoo compositions, hard surface cleaning compositions, and the like, are preferably emulsions/dispersions and generally have a particle size of molecular aggregates, such as micelles and/or vesicles, of greater than about 0.05 &mgr;m, preferably greater than about 0.1 &mgr;m, and more preferably greater than about 0.2 &mgr;m. These compositions can be clear, translucent, or opaque, dependent on the types and concentrations of materials in the compositions.
A. Functionally-Available Cyclodextrin
The present compositions comprise functionally-available cyclodextrin. The functionally-available cyclodextrin in the present compositions is capable of complexing with unwanted molecules that are present on the surfaces being treated with the present compositions. When the surfaces are treated with the present compositions, the functionally-available cyclodextrin complexes with the unwanted molecules, thereby effectively removing and/or reducing the presence of the unwanted molecules on the treated surfaces.
As used herein, the term “functionally-available cyclodextrin” refers to cyclodextrin that is either not complexed with other materials (e.g. uncomplexed, free cyclodextrin) or is complexed with materials that only weakly complex with cyclodextrin, e.g. weakly complexing materials that have a cyclodextrin complexation constant of less than about 5,000 M
−1
, preferably les
DuVal Dean Larry
Reece Steven
Uchiyama Hirotaka
Woo Ricky Ah-Man
Camp Jason J.
Fubara Blessing
Miller Steven W.
Page Thurman K.
The Procter & Gamble & Company
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