Process of making tetrahydropteroylpoly-L-glutamic acid derivati

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides

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530331, 530332, A61K 3702, C07K 500

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active

051533090

ABSTRACT:
The invention is a method of synthesizing tetrahydropteroylpoly-L-glutamic acid derivatives starting from the mono-L-glutamic acid derivatives. The method has the advantage of not requiring any enzymes.

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Nefkens, "Synthesis of alpha-Esters of N-Substituted Glutamic Acid", pp. 39-40.
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McGuire et al, The Journal of Biological Chemistry, vol. 255, No. 12, pp. 5776-5785 (Jun. 25, 1980).
Rees et al, Tetrahedron, vol. 42, No. 1, pp. 117-136 (1986).
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