Process of making tetrahydropteroylpoly-L-glutamic acid derivati

Details Process of making tetrahydropteroylpoly-L-glutamic acid derivati Process of making tetrahydropteroylpoly-L-glutamic acid derivati

1990-07-27

1992-10-06

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530331, 530332, A61K 3702, C07K 500

Patent

active

051533090

ABSTRACT:
The invention is a method of synthesizing tetrahydropteroylpoly-L-glutamic acid derivatives starting from the mono-L-glutamic acid derivatives. The method has the advantage of not requiring any enzymes.

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Rosowsky & Yu Chem. Biol. Pteridines Rev. Biochem. vol. 4, 6th (1979) 273-277.
Rosowsky et al. J. Med. Chem. vol. 27 No. 5 (1984).
Krumdieck, C. L. & Baugh, C. M., Methods Enzymol.; vol. 66, 1980, 523-529.
D'Ari, L. & Rabinowitz, J. C., Methods Enzymol.; vol. 113, 1985, 169-183.
Nefkens, "Synthesis of alpha-Esters of N-Substituted Glutamic Acid", pp. 39-40.
Huennekens et al, Methods in Enzymology, vol. VI, Peptide Proc. Eur. symp. 5th (1963) pp. 802-815 (1963).
McGuire et al, The Journal of Biological Chemistry, vol. 255, No. 12, pp. 5776-5785 (Jun. 25, 1980).
Rees et al, Tetrahedron, vol. 42, No. 1, pp. 117-136 (1986).
Pohland et al, J. Am. Chem. Soc., vol. 73, No. 7, pp. 3247-3252 (Jul. 1951).

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