Process of making spirocycles and analogs thereof

Details Process of making spirocycles and analogs thereof Process of making spirocycles and analogs thereof

1994-05-31

1996-01-16

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 15, 546 16, 546 18, C07D45110, C07D451107

Patent

active

054849233

ABSTRACT:
The present invention is directed to a process of making spirocycles of general structural formula: ##STR1## where R.sub.1 is selected from the group consisting of CO--C.sub.1-3 alkyl, cyano, carboxy, carboxy C.sub.1-6 alkyl ester, carboxamide, C.sub.1-6 alkyl sulfinyl, C.sub.1-6 alkyl sulfonyl, C.sub.1-6 methanesulfonamide and halogen; R.sub.2 is selected from the group consisting of keto or alcohol, R.sub.3 is cyano, resulting in compounds which are Class III antiarrhythmic.

REFERENCES:
patent: 4943635 (1990-07-01), Corey
patent: 5206240 (1994-04-01), Baldwin
Carey et al "A new system for catalytic evautio-selective reduction" Tetrahedron Lett 31 611-614 (1990).

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