Process of making penicillamine

Details Process of making penicillamine Process of making penicillamine

1973-03-29

1976-04-06

Terapane, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603067C, 2603067R, C07C 9910

Patent

active

039489841

ABSTRACT:
Penicillamine and its hydrochloride are made by reacting isobutyraldehyde with elemental sulfur or a sulfur-containing compound and with gaseous ammonia so as to form 2-isopropyl-5.5-dimethyl-thiazoline-.DELTA..sup.3, then reacting the latter compound with substantially anhydrous hydrogen cyanide so as to form the corresponding thiazolidine 4-carbonitrile, thereupon treating the latter compound with an excess of concentrated hydrochloric acid at an elevated temperature and separating the components of the mixture formed and recovering the penicillamine hydrochloride which may then be converted to the free D,L-penicillamine.

REFERENCES:
Asinger et al., "Annual Report for 1967 of Landesant fuer Forschung des Lander Nordrhein--Westfalen," pp. 11-35.
Asinger et al., Ann. Bd 697, pp. 140-157.
Asinger et al., Monatshefte fuer Chemie, 97(5), pp. 1510-1522 (1966).

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