Process of making crystalline Type II aripiprazole

Details Process of making crystalline Type II aripiprazole Process of making crystalline Type II aripiprazole

2006-03-17

2010-02-02

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S367000

Reexamination Certificate

active

07655798

ABSTRACT:
Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.

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“Study on Crystal Transformation of Aripiprazole” The Fourth Japan-Korea Symposium on Separation Technology (1996), pp. 937-940.

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