Process of making cox-2 inhibitors having a lactone bridge

Details Process of making cox-2 inhibitors having a lactone bridge Process of making cox-2 inhibitors having a lactone bridge

1994-09-16

1996-12-17

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30758

Patent

active

055855040

ABSTRACT:
The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##

REFERENCES:
Campbell, et al., J. Chem. Soc., Perkin Trans. 1, No. 8, pp. 1567-1576 (1985).
Ford, et al., J. Org. Chem., vol. 32, No. 1, pp. 173-177 (1967) Eastman Kodak Co., Res. Labs Rochester, NY.
Dikshit, et al., Indian Journal of Chemistry, vol. 29b, pp. 954-960 (1990).

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