Process of making benzylic .alpha.,.alpha.-diflurophosphonates f

Details Process of making benzylic .alpha.,.alpha.-diflurophosphonates f Process of making benzylic .alpha.,.alpha.-diflurophosphonates f

1992-06-12

1993-11-23

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558204, C07F 940

Patent

active

052646076

ABSTRACT:
The disclosure is concerned with providing phosphonic acid-containing derivatives of phenylalanine and optically active isomers thereof, which are functionalized in a manner which makes them suitable for facile incorporation into peptides using standard solid-phase or solution-phase techniques. The disclosure is also concerned with providing an advantageous one-step reaction method for preparing benzylic .alpha.,.alpha.-difluorophosphonates from corresponding benzylic ketophosphonates.

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