Process of making benzylic .alpha.,.alpha.-diflurophosphonates f

Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters

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558204, C07F 940

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052646076

ABSTRACT:
The disclosure is concerned with providing phosphonic acid-containing derivatives of phenylalanine and optically active isomers thereof, which are functionalized in a manner which makes them suitable for facile incorporation into peptides using standard solid-phase or solution-phase techniques. The disclosure is also concerned with providing an advantageous one-step reaction method for preparing benzylic .alpha.,.alpha.-difluorophosphonates from corresponding benzylic ketophosphonates.

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