Process of L-phenylalanine fermentation

Details Process of L-phenylalanine fermentation Process of L-phenylalanine fermentation

1995-06-01

1997-03-25

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435843, C12P 1322

Patent

active

056143923

ABSTRACT:
The present invention provides a process for L-phenylalanine fermentation by coryneform bacterium. The present invention successfully applies an oxystat to control the timing of feeding of molasses so as to maintain low dissolved oxygen tension and low substrate concentrations during the course of fermentation. The oxystat improves fermentation productivity appreciably. Furthermore, the present invention discovers that the proper increases of the oxygen supply rate to the culture decreases product feedback inhibition of phenylalanine formation as phenylalanine concentration increases.

REFERENCES:
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patent: 4755466 (1988-07-01), Yokozeki et al.
patent: 4900669 (1990-02-01), Hatch et al.
Derwent Abs. 87-321672/46 Kludas et al. DD-247231 (Jul. 1987).
Derwent Abs. 75-71529W/43 Ajinomoto KK (J50064485)(May. 1975).
Biotech Abs. 91-10001 Konstantinov et al. "J. Ferment Bioeng" (1991) 71, 5, 350-55.
Biotech Abs. 94-15470 "Biotech Tech." (1994) 8, 11, pp. 843-846.

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