Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from a root – bulb – tuber – corm – or...
Reexamination Certificate
2005-08-02
2005-08-02
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from a root, bulb, tuber, corm, or...
C424S725000
Reexamination Certificate
active
06923993
ABSTRACT:
The present invention is directed to a process of isolating an extract from aEuphorbia obesa(EO) plant by: preparing a sample of said plant comprising removal of the latex material; dissolving said sample with first solvent to form a solution; separating said solution into a liquid and a pulp fraction; and purifying said pulp fraction. The isolated EO extract induces apoptosis and inhibits growth of a cancerous cell. Thus, the present invention is also directed to a method for inducing apoptosis and growth inhibition of a cancerous cell by contacting the cell with an effective amount of the EO extract by the process of the invention. Preferably, the extract is administered both to the tumor directly and intravenously. The preferred lines of cancerous cells are melanoma, non-small cell lung cancer, prostate cancer, breast carcinoma, ovarian cancer, lymphoma and leukemia cells.
REFERENCES:
patent: 6432452 (2002-08-01), Aylward
patent: 9701179 (1998-12-01), None
patent: 9908994 (1999-02-01), None
Internet reference titled “Euphorbia obesaHook. f.” from website http:://www.plantzafrica.com, Feb. 2002, 4 pages.
Vosa et al. Caryologia. 1994. vol. 44, No. 1, pp. 27-34, BIOSIS Abstract enclosed.
Donato Nicholas D.
Donato Nicholas J.
McMurray John S.
Newman Robert A
Perez Margot
Albert, Jr. G. Peter
Donato Nicholas D.
Donato Nicholas J.
Foley & Lardner LLP
Tate Christopher R.
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