Process of in vitro diagnosis of cystic fibrosis

Details Process of in vitro diagnosis of cystic fibrosis Process of in vitro diagnosis of cystic fibrosis

1982-02-08

1984-09-04

Hruskoci, Peter A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 21, 435184, C12Q 134, C12Q 142

Patent

active

044697880

ABSTRACT:
The invention relates to an in vitro process for diagnosing cystic fibrosis, which brings into play conditions, particularly temperatures at which some of the hydrolases released by the cells from the individual under study, particularly .alpha.-mannosidase and acid phosphatase, are subject to greater inactivation kinetics, when the cells originated from individuals affected by the disease or capable of transmitting it, than when said cells were from healthy people. The process thus consists of maintaining such cells, either in natural biological media or in culture media at a temperature within said intervals for a time long enough to appreciate the degree or kinetics of inactivation which can then be correlated to the fact that the individual is either healthy or affected by the disease or liable of transmitting it.

REFERENCES:
patent: 3002893 (1961-10-01), Babson
patent: 3902847 (1975-09-01), Bosch et al.
patent: 3932221 (1976-01-01), Pfleiderer
Chemical Abstracts, 89:127224u, "Reliable Diagnosis of the Major Type of Cystic Fibrosis with Fibroblast Cultures", 1978.
Chemical Abstracts, 91:155608g, "Cystic Fibrosis: Decreased Thermo-Stability of .alpha. Mannosidase in Crude Extracellular Fluids", 1979.
Chemical Abstracts, 91:155595a, "Inhibition of Tamm-Horsfall Glyco-Protein Induction of Alkaline Phosphatase in Cystic Fibrosis Fibroplasts", 1979.
Hosli et al., "Cystic Fibrosis: Leakage of Lysosomal Enzymes and of Alkaline Phosphatase into Extracellular Space," Bio. Chem. & Biophys. Res. Comm., Dec., 1977, pp. 741-748.

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