Process of enriching adherent CD4.sub.+ T cells from monocyte d

Details Process of enriching adherent CD4.sub.+ T cells from monocyte d Process of enriching adherent CD4.sub.+ T cells from monocyte d

1991-01-31

1994-12-20

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

43524021, 43524023, 424 852, C12N 500, A61K 4505

Patent

active

053745493

ABSTRACT:
Peripheral blood mononuclear cells (PBMC) are treated to deplete monocytes and the remaining cells are cultured in a medium containing interleukin-2 (IL-2) and interleukin-4 (IL-4). Nonadherent cells are removed and discarded, and adherent cells are further cultured in a medium of IL-2 and IL-4 which expands the CD4+ T cells population of the PBMC. The expanded, enriched CD4+T cells can be placed in a pharmaceutically acceptable carrier and administered to a mammal with IL-2 to treat a tumor.

REFERENCES:
patent: 4849329 (1989-07-01), Leung et al.
patent: 5108760 (1989-07-01), Irr et al.
patent: 5126132 (1992-06-01), Rosenberg
Melder et al, Cancer Research, 48, pp. 3461-3469 (Jun. 15, 1988).
Hoyer et al, Cancer Research, 46 (1986) pp. 2834-2838.
Kawakami et al, J. of Immunology vol. 142, No. 10, May 1989, pp. 3452-3461.
Reinhold et al, J. Invest. Dermatol 96 (3). 1991, pp. 370-375.

Affiliated with

Also associated with

Rating

Process of enriching adherent CD4.sub.+ T cells from monocyte d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of enriching adherent CD4.sub.+ T cells from monocyte d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of enriching adherent CD4.sub.+ T cells from monocyte d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2385745