Process of determining an immunogenic substance by competition w

Details Process of determining an immunogenic substance by competition w Process of determining an immunogenic substance by competition w

1978-11-27

1981-03-10

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 252316, 424 12, A61K 4300, G01N 3348, G01T 100, B01J 1300

Patent

active

042554110

ABSTRACT:
A process for determining an immunogenic substance present in a sample wherein the immunogenic substance in the sample competes with a distinguishable analog of such substance for available binding sites on an antibody which is highly specific for the immunogenic substance in the sample. The antibody is encapsulated in a semi-permeable microcapsule.
A specific example of the foregoing procedure is the determination of digoxin present in serum wherein the digoxin in the serum competes with radioiodine labeled digoxin for available binding sites on an antibody which is highly specific for digoxin and has been previously encapsulated in semi-permeable microcapsules. The concentration of digoxin in the sample is determined from a standard curve by relating digoxin concentration inversely to the percent of radioiodine labeled digoxin that is complexed to the antibody.

REFERENCES:
patent: 4021364 (1977-05-01), Speiser et al.
patent: 4115534 (1978-09-01), Ithakissios
patent: 4131544 (1978-12-01), Elahi
patent: 4158547 (1979-06-01), Rousseau et al.

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