Process of continuous preparation of disperse colloidal systems

Details Process of continuous preparation of disperse colloidal systems Process of continuous preparation of disperse colloidal systems

1994-09-21

1998-01-06

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

264 46, 424486, 424488, 424494, 427 214, 4272133, 42721331, 42721334, 42721336, A61K 951, B01J 1312

Patent

active

057051968

ABSTRACT:
It comprises: (1) preparing an aqueous phase containing surface active suspensor agents and, optionally, a chemically or biologically active chemical substance; (2) preparing an organic phase containing a biocompatible polymer or monomer and, optionally, a lipid or chemically or biologically active chemical substance; (3) mixing both phases in a continuous manner in a constant average phase-volume ratio, continuously removing a recently formed colloidal suspension; (4) continuously eliminating the solvent from the colloidal suspension; and (5) completely eliminating the organic solvent and part or all of the water in order to obtain the desired concentration of nanospheres or dry product.
Application in biomedicine, pharmacy, medicine, cosmetics, chemical industry, agriculture, veterinary science, etc.

REFERENCES:
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4489055 (1984-12-01), Couvreur et al.
patent: 4798786 (1989-01-01), Tice et al.
patent: 5049322 (1991-09-01), Devissaguet et al.
patent: 5118528 (1992-06-01), Fessi et al.
patent: 5354556 (1994-10-01), Sparks et al.

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