Process for working up the crystallization mother liquor from th

Details Process for working up the crystallization mother liquor from th Process for working up the crystallization mother liquor from th

1991-11-26

1992-09-01

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564302, 564304, C07C20984, C07C20986, C07C20988

Patent

active

051440776

ABSTRACT:
The invention relates to a process for working up to crystallization mother liquor which is obtained in the resolution of the racemate of 1-(4-chlorophenyl)-ethylamine of the formula (I) with S-(-)-N-phenylcarbamoyllactic acid of the formula (II) by removing the ethanol from the ethanolic crystallization mother liquor by distillation in a 1st step and stirring the residue which remains with tert.-butyl methyl ether or toluene in a second step and it being possible to employ the resulting crystalline salt of (R/S)-1-(4-chlorophenyl)-ethylamine and (S)-(-)-N-phenylcarbamoyllactic acid directly again for the resolution of the racemate. The (S)-form of the amine is mainly present in the mother liquor and can be racemised and added to the resolution of the racemate again.

REFERENCES:
patent: 4988734 (1991-01-01), Kraatz et al.

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