Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2003-05-30
2004-09-14
Davis, Brian J. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
Reexamination Certificate
active
06791000
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a process for vapor phase nitration of benzene using nitric acid over molybdenum silica catalyst. The invention particularly relates to a process for the preparation of mono-nitrobenzene wherein the nitration of benzene is carried out in vapor phase using molybdenum silica catalyst and nitric acid. By the process of present invention nitrobenzene has been prepared in high yield in a continuous process without any waste byproduct formation making it an environment friendly process.
BACKGROUND OF THE INVENTION
Major part of nitrobenzene (95% or more) produced is converted to aniline, which has hundreds of downstream products. Nitrobenzene also is used as a processing solvent in specific chemical reactions. Conventionally nitrobenzene is produced by liquid phase reactions employing mixed acids. A sulfuric acid
itric acid mixture is the most commonly used nitrating agent. Generation of large amount dilute sulfuric acid, organic wastes and products of their neutralization makes the benzene nitration one of the most environmentally harmful processes.
Vapor-phase nitration of benzene to nitrobenzene over zeolite is expected to be a clean process without sulfuric acid waste. A number of heterogeneous catalysts have been proposed for this process.
In the prior art, vapor phase nitration of aromatic compounds, benzene and toluene at temperature ranging from about 275° C. to about 310° C. is described in McKee and Wilhelm, Industrial and Engineering Chemistry, 28(6), 662-667 (1936) and U.S. Pat. No. 2,109,873. McKee and Wilhelm catalyzed their reaction with silica gel. Bauxite and alumina were reported to be ineffective as catalyst in the vapor phase nitration of benzene.
U.S. Pat. No. 2,431,585 describes vapor phase nitration of aromatic hydrocarbons at temperature from 130° C. to 430° C., using metal phosphates of calcium, iron, magnesium and solid supported phosphoric acid catalysts.
U.S. Pat. No. 4,551,568 describes the vapor phase nitration of benzene over solid mixed oxide catalyst comprising WO
3
and MoO
3
, which exhibited a fairly high and stable activity.
U.S. Pat. No. 3,966,830, Jpn. Pat. No. 58-157748 and U.S. Pat. No. 4,426,543 describe the nitration of aromatics using zeolite catalysts. The lower conversion of benzene to nitrobenzene and faster deactivation of zeolite catalysts are the drawbacks of these processes for commercial application.
U.S. Pat. No. 5,030,776 describes a process for nitrating benzene using nitric acid as a nitrating agent under continuous or intermittent feeding of sulfuric acid as a catalyst on a solid carrier. Vapor phase nitration of benzene has been claimed in U.S. Pat. No. 5,004,846 wherein nitric acid is used as a nitrating agent and a composite oxide or acidic sheet clay mineral ion exchanged with polyvalent metal as a catalyst.
PCT International Patent Application No. WO 96/36587 describes a solvent free process for the nitration of aromatic compounds in which the aromatic compound is reacted with nitric acid in presence of an acid anhydride wherein the process is catalyzed by an aluminosilicate catalyst. Nitric acid and acid anhydride react with each other in-situ to form acyl nitrate and this acts as a nitrating agent for aromatic compounds. For example benzene, naphthalene, anthracene, toluene etc. are nitrated to mononitrated compounds. A mixture of ortho-, meta-, and para-nitrotoluenes is obtained which is then distilled at a pressure of 30 mmHg and a temperature of 30° C. to remove acetic acid as a byproduct.
These prior art processes for the vapor phase nitration of benzene for the preparation of nitrobenzene have the limitations of low conversions low space-time yield, low yield, short catalyst life, contamination of the products by undesirable by-products and the complicated nature of catalysts. These prior art processes use concentrated nitric acid as nitrating agent, which leads to the oxidation products deactivating the catalyst.
OBJECTS OF THE INVENTION
The main object of the present invention is to provide a process for vapor phase nitration of benzene using nitric acid and over molybdenum silica catalyst.
Another object of the present invention is use of ethyl silicate-40 as silica source for the preparation of high surface area MoO
3
/SiO
2
catalyst.
Yet another object of the present invention is the use of xMoO
3
:(1−x) SiO
2
catalyst, where x=0.05-0.2, preferably x=0.2 for vapor phase nitration of benzene using nitric acid and over molybdenum silica catalyst.
It is another object of the invention to provide a process for the nitration of benzene which is simple and easy to scale up.
It is yet another object of the invention to provide a process for the nitration of benzene which avoids the use of sulphuric acid.
It is another object of the invention to provide a process for the nitration of benzene which uses easily separable solid catalyst with negligible deactivation and long life.
It is a further object of the invention to provide a process for the nitration of benzene which enables good conversion (more than 80%) and 100% selectivity for nitrobenzene.
SUMMARY OF THE INVENTION
Accordingly the present invention provides a process for the vapor phase nitration of benzene, which comprises nitrating benzene with nitric acid over a molybdenum silica catalyst and separating the desired product.
In one embodiment of the invention, benzene is nitrated with nitric acid in the presence of a carrier gas comprising an inert gas.
In another embodiment of the invention, the nitration is carried out in a conventional downflow reactor containing inert ceramic packing as preheater.
In another embodiment of the invention, the molybdenum silica catalyst comprises a granulated molybdenum silica catalyst of composition MoO
3
:(1−x) SiO
2
, wherein x=0.05-0.2.
In another embodiment of the invention, the catalyst is used without a promoter.
In another embodiment of the invention, the catalyst is used with a promoter comprising 0.5-2% of a transition metal oxide.
In another embodiment of the invention, the nitration is carried out at a temperature in the range of 100-250° C. and at a reactant weight hourly space velocity (WHSV) in the range of 0.1 to 1.0.
In another embodiment of the invention, resulting product is condensed and then washed with alkali to obtain the desired product.
In another embodiment of the invention, the catalyst used is in the form of a pellet.
In another embodiment of the invention, the mesh size of granulated molybdenum silica catalyst used is in the range of −10 to +20 mesh size.
In another embodiment of the invention, the catalyst used is MoO
3
:(1−x) SiO
2
where x is 0.2.
In another embodiment of the invention, the MoO
3
/SiO
2
catalyst used is in amorphous or crystalline form.
In another embodiment of the invention, the molybdenum silica catalyst is in amorphous form.
In another embodiment of the invention, the molybdenum silica catalyst is used along with a promoter comprising 1-2% transition metal oxides selected from the group consisting of Fe
2
O
3
, CuO, NiO and Co
3
O
4
.
In another embodiment of the invention, the promoter is Fe
2
O
3
.
In another embodiment of the invention, the nitric acid used is 10 to 70% nitric acid.
In another embodiment of the invention, the molar ratio of nitric acid to benzene is in the range of 4:1 to 1:4.
In another embodiment of the invention, the ratio of nitric acid to benzene is 1:2.
In another embodiment of the invention, the nitration is carried out at a temperature in the range of 120-200° C.
In another embodiment of the invention, the inert gas used is selected from the group consisting of nitrogen, helium and argon.
In another embodiment of the invention, the reactant weight hourly space velocity used is in the range of 0.15 to 0.5.
The present invention also provides a process for vapor phase nitration of benzene using nitric acid over molybdenum silica catalyst which comprises reacting benzene with nitric acid along with an inert gas as carrier gas in a conventi
Dongare Mohan Keraba
Malshe Kusum Madhukar
Patil Pratap Tukaram
Council of Scientific and Industrial Research
Davis Brian J.
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