Process for vaccine preparation

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

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A61K 3902

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active

041573900

ABSTRACT:
A vaccine comprising an antigen selectively adsorbed onto erythrocytes possessing their natural surface characteristics. When the antigen is the K88a,b/adhesion factor of E. coli and the erythrocytes are chicken erythrocytes, the vaccine is especially suitable for reducing the incidence of neonatal diarrhoea in pigs if it is administered parenterally to a sow about three weeks prior to parturition.

REFERENCES:
Neter et al., J. Bacteriol, 66:424-428, (1953), "The Requirement of Electrolytes for the Adsorption of Escherichia Coil Antigen by Red Blood Cells".
Kabat et al., Experimental Immunochemistry, 2nd Ed., (1961), C. C. Thomas, Springfield, Ill., p. 97, Agglutination, 119-124, "Adsorption of Antigens on Untreated Erythrocytes-Coupling of Antigens to Erythrocytes".
Jones et al., J. Gen. Microbiol. 84(1): 135-144, Jan.-Feb. 1974, "The Association of K88 Antigen With Haemagglutinating Activity in Porcine Strains of E. Coli".
Jones et al., Am. Jl. Clin. Nutr., (1974), 27(12):1441-1449, "Contribution of the K88 Antigen of Escherichia Coli to Enteropathogenicity; Protection Against Disease by Neutralizing the Adhesive Properties of K88 Antigen".

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