Surgery – Radioactive substance applied to body for therapy – Radioactive substance placed within body
Patent
1985-05-09
1989-03-28
Howell, Kyle L.
Surgery
Radioactive substance applied to body for therapy
Radioactive substance placed within body
128 11, A61B 1900
Patent
active
048154466
ABSTRACT:
A method of controlling metastasis of a cancerous tumor in a patient is disclosed. The method comprises administering a perfluorocarbon compound (PFC) emulsion to the patient at intervals of from about 3 to 14 days during a treatment period. PFC emulsion is administered initially in an amount of from about 2 to about 15 milliliters per kilogram of patient body weight. Subsequently administration of PFC emulsion do not exceed about 15 milliliters per kilogram of body weight. Oxygen is administered daily for at least three days following each administration of PFC emulsion & preferably every day during the treatment period. Radiation and/or chemothereapeutic agents may be administered to the patient in conjunction with the administration of PFC emulsion and oxygen.
REFERENCES:
patent: 4434788 (1984-03-01), Nakatsugawa
"Perfluorochemical Possibly Applies to Brain Tumor Therapy", Mitsuyama et al., 1982, Nygoya Health University.
"Radiation Sensitization of Artificial Blood Substitute (Fluosol-DA)", Hishikawa-Itro et al., (Summarized Translation by N. Washio) 1983.
"Use of Perfluorochemical Emulsions to Improve Oxygenation in Solid Tumors", Rockwell et al., Yale University, 1983.
"Experimental Studies on the Possible Combined Chemotherapy to Neoplasms with Fluosol-DA Infusion", Ohyanagi et al., 1983, Advances in Blood Substitute Research, pp. 315-320.
"Synergistic Effect of Perfluorochemicals on BCNU Chemotherapy-Experimental Study in a 9L Rat Brain-Tumor Model", Kuwamura et al., Kobe Univ., Japan.
"Increased Efficacy of Radiotherapy in Mice Treated with Perfluorochemical Emulsions Plus Oxygen," B. Teicher and S. Rockwell (Abstracted from 1983 American Association of Cancer Research Meeting, May 25-28).
"Perfluorocarbon Emulsions in Cancer Therapy: Preliminary Observations on Presently Available Formulations," Robert L. Goodman, M.D., Robert E. Moore, Ph.D., Mary E. Davis, B.S., David Stokes, B.S., and John M. Yuhas, Ph.D.
European Patent Application Ser. No. 83304632.9 to R. E. Moore Published Apr. 18, 1974 (Publication No. 0 105 584).
"Enhancement of Anticancer Drug Efficacy by a Perfluorocarbon Emulsion (PFC)," B. A. Teicher and C. M. Rose (Abstracted from 1984 American Association of Cancer Research Meeting).
"Perfluorochemical Emulsions Can Increase Tumor Radiosensitivity," B. A. Teicher and C. M. Rose, Science, vol. 223, Mar. 2, 1984.
"Macrophages and Cancer Metastasis," I. J. Fidler and G. Poste.
"Metastasis: Tracking the Seeds of Cancer," K. White, Medical World News, Dec. 26, 1983.
"Ultrastructure of Tumoricidal Peritoneal Exudate Cells Stimulated In Vitro by Perfluorochemical Emulsions," M. L. Miller, J. D. Stinnett and L. C. Clark, Jr., J. Reticuloendothelial Soc., vol. 27, No. 2, Feb. 1980.
Alpha Therapeutic Corporation
Citrin Randy
Howell Kyle L.
LandOfFree
Process for treating metastasis of cancerous tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for treating metastasis of cancerous tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for treating metastasis of cancerous tumors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1652095