Process for treating lameness administration of a...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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Reexamination Certificate

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07915239

ABSTRACT:
The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from arthritis or from fractures, of an effective amount of a bisphosphonic acid derivative of formula:in which:R1represents a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono(C1-C4)alkylamino or a di(C1-C4) alkylamino;R2represents a halogen atom, a linear alkyl comprising from 1 to 5 carbon atoms which is unsubstituted or substituted with a group chosen from a chlorine atom, a hydroxyl, an amino, a mono(C1-C4)alkylamino or a di(C1-C4)alkylamino; a (C3-C7) cycloalkylamino,or R2represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridyl-methyl, a 1-pyridyl-1-hydroxymethyl, an imidazolyl-methyl or a 4-thiomorpholinyl,of one of its pharmaceutically acceptable salts or of one of its hydrates.

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Stedman's Medical Dictionary 27th edition (online) definitions of arthritis; osteoarthritis, inflammation.
Siris (A Potent New Bisphosphonate for Paget's Disease of Bone, 1996, The American Journal of medicine, vol. 101, pp. 339-340).
Lepage et al. ,L'emploi d'un bisphosphonate (APD) dans la Prévention des exostoses chez le poney Shetland. Etude Préliminaire. Ann. Méd. Vét. . 1988, 132, 391-399.

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