Process for transport of agents across the skin and compositions

Details Process for transport of agents across the skin and compositions Process for transport of agents across the skin and compositions

1993-08-20

1996-06-18

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514588, 514724, A61K 31535, A61K 3117, A61K 31045

Patent

active

055277977

ABSTRACT:
New and improved method for the transdermal administration of agents is provided utilizing iontophoresis in conjunction with a water-insoluble, stratum corneum-lipid modifier. The lipid modifier may be used prior to iontophoresis or simultaneously therewith. The lipid modifier may be selected from a wide variety of moieties of the general formula R--X where R is a C.sub.5 to C.sub.28 alkyl or unsaturated alkyl and X is a member of the following: 1,3-dioxane; 1,3-dioxolane; lactam; morpholine; --COOH; --OH; --COOR'; --C--N(R').sub.2 ; cyclo ethylene and propylene carbonates; --CONH.sub.2 ; --(CH.sub.2 --CH.sub.2 O).sub.n H; ##STR1## acetals, and hemiacetals; and wherein R' is lower alkyl (e.g., C.sub.1 to C.sub.3) and n is an integer of from 1 to 20. Optionally there may be present a polar, water-soluble chemical compound from the group of alcohols, glycols, lactams, dioxolanes, esters, ureas, morpholine and the like. Compositions and articles useful in the processes of the present invention are also provided.

REFERENCES:
patent: 4861764 (1989-08-01), Samour et al.

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