Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-on

Details Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-on Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-on

1995-01-18

1995-11-28

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 15, 548407, 548517, 544 70, 544148, 540480, 540543, 540596, 549333, 549373, C07D40502, C07D31904

Patent

active

054709814

ABSTRACT:
An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where .alpha.-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahy dro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H pyrrole-3-carboxamide, as well as other valuable intermediates used in the processes and prodrugs which are bioconverted to hypolipidemic and hypocholesterolemic agents and pharmaceutical compositions of the same.

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