Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-10-14
1995-08-29
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514343, 514422, 514423, 514427, 514183, 514212, 5142355, 540480, 540602, 544141, 546208, 546281, 548400, 548518, 548523, 548537, 548540, 548560, 548561, 548562, A61K 3140, A61K 3144, A61K 31445, C07D21114
Patent
active
054460549
ABSTRACT:
An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where .alpha.-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahy dro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide, as well as other valuable intermediates used in the processes and prodrugs which are bioconverted to hypolipidemic and hypocholesterolemic agents and pharmaceutical compositions of the same.
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CA 115:135870x Inhibitors . . . Pyrrole nucleus. Roth et al., p. 959, 1991.
CA 115:29107u Preparation of . . . Salts thereof. Roth pp. 753-754, 1991.
Butler Donald E.
Le Tung V.
Nanninga Thomas N.
McKane Joseph K.
Tinney Francis J.
Warner-Lambert & Company
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