Process for trans-6- 2-(substituted-pyrrol-1-yl)alkyl!pyran-2-on

Details Process for trans-6- 2-(substituted-pyrrol-1-yl)alkyl!pyran-2-on Process for trans-6- 2-(substituted-pyrrol-1-yl)alkyl!pyran-2-on

1995-05-15

1996-04-23

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 15, 540543, 540596, 544 70, 544148, 548407, 548517, 549333, 549375, C07D21110

Patent

active

055104886

ABSTRACT:
An improved process for the preparation of trans-6- 2-(substituted-pyrrole-1-yl)alkyl!pyran-2-ones by a novel synthesis is described where .alpha.-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N, 4-diphenyl-1- 2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl!-1H-pyrrol e-3-carboxamide, as well as other valuable intermediates used in the processes and prodrugs which are bioconverted to hypolipidemic and hypocholesterolemic agents and pharmaceutical compositions of the same.

REFERENCES:
patent: 4647576 (1987-03-01), Hoefle et al.
patent: 4681893 (1987-07-01), Roth
patent: 5003080 (1991-03-01), Butler et al.
patent: 5097045 (1992-03-01), Butler et al.
patent: 5103024 (1992-04-01), Millar et al.
patent: 5124482 (1992-06-01), Butler et al.
patent: 5149837 (1992-09-01), Butler et al.
patent: 5155251 (1992-10-01), Butler et al.
patent: 5273995 (1993-12-01), Roth
J. Med. Chem., 1991, 34, 357-366 B. D. Roth, et al.
Tetrahedron Letters, vol. 33, No. 17, pp. 2283-2284 1992, K. L. Baumann, et al.
Tetrahedron Letters, vol. 33, No. 17, pp. 2279-2282 1992, P. L. Brower, et al.
B. D. Roth, et al., J. Med. Chem., 1990, 33:1, pp. 21-31, "Inhibitors of Cholesterol Biosynthesis".

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