Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-02-01
1991-03-26
Wax, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548537, C07D207325, C07D20734
Patent
active
050030809
ABSTRACT:
An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-(4-fluorophenyl)-2-(1-methylethyl)-N-4-diphenyl-1-[2-tetrah ydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-.alpha.-[2-methyl-1-oxopropyl]-.gamma.-oxo-N,.beta.-diphenylbenze nebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahy dro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.
REFERENCES:
patent: 3960941 (1976-06-01), Wiegand
patent: 4681893 (1987-07-01), Roth
Majewski et al., Tetrahedron Letters, 25, 1984, pp. 2101-2104.
Butler Donald E.
Deering Carl F.
Millar Alan
Nanninga Thomas N.
Roth Bruce D.
Tinney Francis J.
Tsung Frederick F.
Warner-Lambert & Company
Wax Robert A.
LandOfFree
Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-on does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-on, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-on will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-618294