Process for total synthesis of pladienolide B and...

Details Process for total synthesis of pladienolide B and... Process for total synthesis of pladienolide B and...

2011-02-08

2011-02-08

Desai, Rita J (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

07884128

ABSTRACT:
Process for producing compound of Formula:wherein P2, P3and R2are the same as defined below, characterized by comprising reacting a compound represented by Formula (7):wherein P3means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8):wherein P2means a protecting group for hydroxy group; and R2means a phenyl group which may be substituted, in the presence of a base.

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Kanada et al., “Total Synthesis of the Potent Antitumor Macrolides Pladiendolide B and D”, Chem. Inform, vol. 38, Issue 40, Oct. 2, 2007, pp. 4350-4355.

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