Process for thymosin .alpha..sub.1

Details Process for thymosin .alpha..sub.1 Process for thymosin .alpha..sub.1

1981-09-08

1983-02-15

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435193, C12P 2100, C12N 910

Patent

active

043741975

ABSTRACT:
A process is described for the preparation of thymosin .alpha..sub.1 from desacetylthymosin .alpha..sub.1 in the presence of an acetylating agent and a biologically active ribosome preparation. Thymosin .alpha..sub.1 is useful in increasing T-cell numbers and normalizing immune function in patients with thymic dependent primary immunodeficiency diseases and in cancer patients who are immunodepressed.

REFERENCES:
patent: 4293455 (1981-10-01), Merrifield et al.
Palmeter, R. D. et al., Proc. Natl. Aca. Sci. 75, 9498, (1928).
Granger et al., Proc. Nat. Acad. Sci. 73, 3010-3014, (1976).
Wong et al., Biochemistry, vol. 19, pp. 3233-3238, (1980).
Bloemendal, Science, vol. 197, pp. 127-138, (1977).
Woodford et al., The Journal of Biological Chemistry, vol. 254, No. 12, pp. 4993-4999, (1979).

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