Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-04-24
1998-12-15
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31355
Patent
active
058497862
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/FR94/01176 filed Oct. 7, 1998.
BACKGROUND OF THE INVENTION
1. The Field of the Invention
The present invention relates to the preparation of new compositions intended for the prevention and/or treatment of herpes outbreaks.
2. Discussion of the Background
Herpes is an extremely contagious disease caused by a type 1 or 2 Herpes simplex virus, the sole reservoir of which is man.
It can attack the skin or mucous membranes and is spread by simple contact, increasing in proportion the number of individuals exposed to the risks related to this disease. Herpetic primary phase is especially observed in children, where it appears as very painful, pruriginous vesicular lesions which often burst and which often attack the mouth and tongue.
In addition to being a nuisance (pain, stress, appearance), herpes is a disease which can have serious consequences, in particular for people in poor health, pregnant women or neonates, and in cases of eye complaints.
There currently exists no effective treatment against this viral disease. Certain therapies can bring relief during eruptions and can possibly reduce the duration thereof but do not prevent their development. This is the case with the most widely used of them: acyclovir marketed by Wellcome Laboratories under the name Zovirax.RTM..
Flavonoids are polyphenols which contain a skeleton based on 15 carbon atoms resulting from the fusion of two aromatic units, one of which derives from benzene and the other from phenylpropane. The most widespread are the anthocyanins, flavones and flavonols which can exist either in the free form or bonded to one or more sugars (heterosides).
Bioflavonoids or citroflavonoids or vitamin P complex have been known first of all for their favourable activity on blood vessels, by decreasing capillary permeability and fragility, and their synergic activity with ascorbic acid. They derive from flavones, of general formula I: ##STR1##
Semisynthetic flavone derivatives have been prepared, for example, in Applications EP 290,915 or EP 319,412. Different groups of flavone derivatives have been used for pharmaceutical applications other than those initially described.
EP 505,937 describes the preparation of flavone derivatives containing carbamoyl and sulfate groups and their use for their anti-elastase properties.
Flavone derivatives have been proposed for their activity in the treatment of cystinic lithiasis, as an anti-neoplastic or smooth muscle relaxant or in the treatment of diabetes.
EP 183,169 relates to halohydroxyflavones and to their use in medicaments for the treatment of hyperthyroidism.
In Application EP 450,588, derivatives of 3-oxoalkylflavone type are prepared and their hypocholesterolemic action is reported.
Antiviral compositions containing a combination of an antiviral agent and a glycoside which can derive from flavones make it possible to decrease the side effects commonly observed and are described in EP 312,222.
Application EP 19,081 was filed for new substituted flavone derivatives, used for the preparation of medicaments intended to combat Rhinoviruses and Enteroviruses.
Phosphorylated flavonoid derivatives are proposed in EP 543,555 for their activity, in particular against HIV.
SUMMARY OF THE INVENTION
The Applicant has surprisingly revealed the preventive and/or curative activity against herpes outbreaks of compositions containing non-phosphorylated flavonoids, and more particularly citroflavonoids.
The subject of the present invention is therefore the use of at least one active principle from the flavonoid family for the preparation of compositions intended for the treatment and/or the prevention of herpes.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The flavonoids are natural flavonoids and more particularly citroflavonoids and semisynthetic flavone derivatives.
Flavonoid heterosides are advantageously used for the preparation of the compositions. The flavonosides contain one or more saccharide units, which can especially be rutinose, mannose, glucose, and the like.
The usef
REFERENCES:
Wilkinson 117CA: 205185U 1992.
Konoshima et al. 111 CA 224819 X 1989.
Bidel Christian-Georges
Poirson Jean
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