Process for the treatment of patients suffering from drepanocyto

Details Process for the treatment of patients suffering from drepanocyto Process for the treatment of patients suffering from drepanocyto

1980-05-19

1982-06-15

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31435

Patent

active

043351280

ABSTRACT:
This invention relates to a process for the treatment of patients suffering from drepanocytosis, comprising administering to said patients a therapeutically effective dosage of a pyridine derivative having the formula: ##STR1## in which X is oxygen or sulfur; R is oxygen or a phenyl optionally substituted with at least a halogen, lower alkyl, lower alkoxy, nitro, amino, sulfonylamino, aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl or methylenedioxy group; styryl, naphthyl, thienyl or benzhydryl optionally substituted with at least a halogen, lower alkyl, lower alkoxy, aryl, nitro, amino, sulfonylamino, carboxyl, alkoxycarbonyl, cyano, hydroxymethyl or methylenedioxy group; benzoyl optionally substituted with at least a halogen, lower alkyl, lower alkoxy, nitro, amino or sulfonylamino group; R.sub.1 and R.sub.2 each represent at least one atom or group selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro or amino; R.sub.3 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro or amino; and n is zero or an integer from 1 to 15; and R.sub.3 may have a different meaning in each CHR.sub.3 group when n is greater than 1; or a pharmaceutically acceptable acid addition salt or quaternary ammonium derivative of said compound.

REFERENCES:
patent: 4051141 (1977-09-01), Castaigne
Ann. Soc. Belge Med. Trop., 1969, 49, 2, 205-210, "Raper".
The Journal of International Medical Research, vol. 4, No. 6, 1976, pp. 375-381, "Mackenzie et al.".

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