Process for the treatment of patients suffering from drepanocyto

Details Process for the treatment of patients suffering from drepanocyto Process for the treatment of patients suffering from drepanocyto

1978-06-20

1980-07-01

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31435

Patent

active

042106494

ABSTRACT:
This invention relates to a process for the treatment of patients suffering from drepanocytosis, comprising administering to said patients a therapeutically effective dosage of a pyridine derivative having the formula: ##STR1## in which X is oxygen or sulfur; R is oxygen or a phenyl radical optionally substituted with at least a halogen atom or a lower alkyl, lower alkoxy, nitro, amino, sufonylamino, aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl or methylenedioxy group; a styryl, naphthyl, thienyl or benzhydryl radical optionally substituted with at least a halogen atom or a lower alkyl, lower alkoxy, aryl, nitro, amino, sulfonylamino, carboxy, alkoxycarbonyl, cyano, hydroxymethyl or methylenedioxy group; or a benzoyl radical optionally substituted with at least a halogen atom or a lower alkyl, lower alkoxy, nitro, amino or sulfonylamino group; R.sub.1 and R.sub.2 represent each at least an atom or group selected from hydrogen, halogen, or a hydroxy, lower alkyl, lower alkoxy, nitro or amino group; R.sub.3 is hydrogen, halogen, or a hydroxy, lower alkyl, lower alkoxy, nitro or amino group; and n is zero or an integer from 1 to 15; and the symbols R.sub.3 may have different meanings in each radical CHR.sub.3 when n is greater than 1, or a pharmaceutically acceptable acid addition salt or quaternary ammonium derivative of said compound.

REFERENCES:
patent: 4051141 (1977-09-01), Castaigne
Ann. Soc. Belge Med. Trop, 1969, 49, 2, 205-210, "Raper".
The Journal of International Medical Research , vol. 4, No. 6, 1976, pp. 375-381, "Mackenzie et al.".

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