Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1994-12-07
1996-12-24
Spear, James M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424489, 514951, A61K 920
Patent
active
055871780
ABSTRACT:
The invention relates to a process for the treatment of dried aspartame characterized in that, in a first separation step, particles smaller than 50 .mu.m are removed, with the aid of a stream of air, from aspartame having a particle size distribution with which more than 5 wt. % of the aspartame has a particle size of less than 20 .mu.m and more than 10 wt. % of the aspartame has a particle size of more than 400 .mu.m, and that in a second separation step the product resulting from the first step is subjected to a screening step using a screen that separates at a value between 150 and 250 .mu.m, after which the fraction of the smaller particles thus obtained is recovered as a first product and the fraction of the larger particles is recovered as a second product or is optionally subjected to a further separation step using a screen that separates at a value between 400 and 1000 .mu.m, the fraction of smaller particles thus obtained being recovered as the second product. Aspartame having a particle size distribution in which at least 94% of the particles are larger than 20 .mu.m and smaller than 250 .mu.m appears to present exceptionally good properties as regards processability and dissolution rate.
REFERENCES:
patent: 4594252 (1986-06-01), Niemczyk
patent: 4816268 (1989-03-01), Tsau
Holland Sweetner Company V.o.F.
Spear James M.
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