Process for the synthesis [R-(R*-,R*-)]-5-(3-chlorophenyl-3-[2-(

Details Process for the synthesis [R-(R*-,R*-)]-5-(3-chlorophenyl-3-[2-( Process for the synthesis [R-(R*-,R*-)]-5-(3-chlorophenyl-3-[2-(

1994-09-20

1995-08-01

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26320

Patent

active

054381487

ABSTRACT:
The invention is the simultaneous addition of boron tribromide and a solution of [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2- oxazolidinone in methylene chloride to methylene chloride while maintaining a constant ratio of 2.10:1.00 of boron tribromide to the substrate [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2- oxazolidinone at a temperature of -5.degree. C. to 10.degree. C. gives [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-hydroxyoxyphenyl)-1-methylethyl]-2 -oxazolidinone in an isolated yield of 86.7% and a purity of 98.7%.

REFERENCES:
patent: 5061727 (1991-10-01), Bloom et al.

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