Process for the synthesis of vitamin E

Details Process for the synthesis of vitamin E Process for the synthesis of vitamin E

1999-03-31

2000-05-23

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31172

Patent

active

060667451

ABSTRACT:
A process for the manufacture of d,1-.alpha.-tocopherol by the acid catalyzed condensation of trimethylhydroquinone with isophytol is provided, in which the condensation is carried out in the presence of not more than about 0.4 weight percent, based on the weight of isophytol, of a sulfur-containing acid catalyst such as sulfuric acid, methanesulphonic acid, ethanesulphonic acid, trifluoromethanesulphonic acid, p-toluenesulphonic acid, fluorosulphonic acid and mixtures thereof, and in a solvent which is ethylene or propylene carbonate or a mixture of both carbonates, or a mixture of one or both of the carbonates and a non-polar solvent.

REFERENCES:
patent: 2411969 (1946-12-01), Karrer
patent: 2723278 (1955-11-01), Surmatis et al.
patent: 3708505 (1973-01-01), Greenbaum et al.
M. Kajiwara, et al., "The Synthesis of Regiospecifically .sup.13 C-Labeled .alpha.-Tocopheryl Acetate," Heterocycles vol. 15, No. 2, pp. 1209-1212 (1981).
S. Urano and M. Matsuo, "The Synthesis of C-13 Labeled Vitamin E, [2a-.sup.13 C] all-rac-.alpha.-Tocopherol.sup.1 " Heterocycles, vol. 22, No. 9, pp. 1975-1977 (1984).
International Search Report dated May 30, 1997 corresponding to PCT/EP97/00324 (WO 97/28151).

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