Process for the synthesis of vincamine and related indole alkalo

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546 70, C07D46100, C07D45500

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active

043799353

ABSTRACT:
A process is taught for the synthesis of vincamine and related indole alkaloids, according to which, through only two steps and through a novel synthesis intermediate, namely the glycidic ester, having the formula ##STR1## wherein R" represents --COOCH.sub.3 or --COOCH.sub.2 CH.sub.3, 1-ethyl-1,2,3,4,5,6,7,12b-octahydroindole[2,3-a]quinolizine-1-carboxaldehy de is reacted with a haloester in the presence of a base and the glycidic ester is converted to vincamine or apovincamine or like esters by reaction with a Lewis acid or a mineral acid, the reaction products being subsequently separated by chromatography.

REFERENCES:
patent: 3755333 (1973-08-01), Szantay et al.
patent: 4033969 (1977-07-01), Sevenet et al.
patent: 4267330 (1981-05-01), Kuehne

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