Process for the synthesis of vinblastine and leurosidine

Details Process for the synthesis of vinblastine and leurosidine Process for the synthesis of vinblastine and leurosidine

1979-12-05

1981-12-15

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D51904

Patent

active

043058752

ABSTRACT:
The invention provides a process for the preparation of leurosidine or vinblastine, which comprises hydroxylating and reducing .DELTA..sup.20' dehydroxy-20' vincaleucoblastine corresponding to formula (II): ##STR1##

REFERENCES:
patent: 4144237 (1979-03-01), Kutney
Mangeney, et al., J. Am. Chem. Soc., vol. 101(8) pp. 2243-2245, 04/11/79.
Langlois, et al., Tetrahedron Letters, 1976, (14), pp. 1099-1102.
Kutney, et al., Canadian J. Chemistry, vol. 56, (1), pp. 62-70, 01/78.
Fieser, et al., Reagents for Organic Synthesis, Jon Wiley & Sons, Inc., New York, pp. 1150-1151 (1967).

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