Process for the synthesis of trans-alkenoic acids, use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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Details

C514S557000, C514S558000, C554S223000

Reexamination Certificate

active

06852759

ABSTRACT:
The present invention relates to a process for the preparation of trans-alkenoic acids of general formula CH3—(CH2)n—CH═(CH2)mCO2H where n=4 to 9 m=8 to 16. More particularly, the present invention relates to a process for the preparation of trans-tetracos-15-enoic acid, which is a bioactive constituent possessing dose-related hepatoprotective activity. The present invention also relates to the use thereof for hepatoprotection.

REFERENCES:
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Mit Sumarn Tsujimoto,J. Soc. Chem. Ind. Japan, 1927, 30(12):868-873 with English abstract.
JB Hale et al.,J. Am. Chem. Soc., 1930, 52:4536-4539.
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E. Klenk,Chemical Abstract, 1926, 21:54.
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J.B. Hale et al.,J. of American Chem. Soc., 1930, 52:4536-4539.
A. Müller et al.,Chemische Berichte, 1939, 72:615-619.
J. March, “Advanced Organic Chemistry”, 1985, 412-413.
Sharon Arrol et al.,Chem. Abstracts, 2000, 150(2).
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PCT search report.

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