Process for the synthesis of the levodopa

Details Process for the synthesis of the levodopa Process for the synthesis of the levodopa

1989-07-03

1990-10-09

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

562446, 558354, 558346, C07C25533

Patent

active

049622234

ABSTRACT:
New process for the synthesis of the levodopa, L-(-)-2-amino-3-(3,4-dihydyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with d-camphorsulfonic acid, or with a salt thereof, the d,l-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and demethylation, by means of concentrated solutions of haloid acids, of the d-2-amino-3-(3,4-dimethoxyphenyl)propionitrile and of salts thereof.

REFERENCES:
patent: 3366679 (1968-01-01), Reinhold et al.
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patent: 3890379 (1975-06-01), Schwartz
patent: 4072698 (1978-02-01), Hylton et al.
patent: 4183865 (1980-01-01), Hohnjec et al.
patent: 4350641 (1982-09-01), Degner et al.
Koshigoe et al., Chem. Abst., vol. 109, #54332x, (1988).
Nussim et al., Chem. Abst., vol. 102, #149784r, (1985).

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