Process for the synthesis of the .alpha.-(-methyl-ethyl)-3,4-dim

Details Process for the synthesis of the .alpha.-(-methyl-ethyl)-3,4-dim Process for the synthesis of the .alpha.-(-methyl-ethyl)-3,4-dim

1990-04-25

1992-03-17

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

549549, 564265, 568442, C07C25320

Patent

active

050970585

ABSTRACT:
New process for the synthesis of the .alpha.-(1-m.ethylethyl)-3,4-dimethoxyacetonitrile of formula (I): ##STR1## which is known as an intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the isobutyryl-3,4-dimethoxybenzene of formula (II): ##STR2## which, by means of the Darzens condensation, gives an epoxyester which, by alkaline hydrolysis and subsequent decarboxylation, gives the .alpha.-(1-methylethyl)-3,4-dimethoxybenzeneacetaldehyde. This product is reacted with hydroxylamine to obtain the corresponding oxime that, by dehydration, gives the nitrile of formula I.

REFERENCES:
patent: 3261859 (1966-07-01), Dengel
patent: 3415866 (1968-12-01), Suh
patent: 3435075 (1969-03-01), Glamkowski et al.
patent: 3997608 (1976-12-01), Suh
patent: 4235807 (1980-11-01), Fuhlhage
patent: 4456562 (1984-06-01), Tamura et al.
patent: 4593042 (1986-06-01), Liang
Japanese Patent Publication J5 3092-732, 8-78 (Abstract).
Hungarian Patent HU T032-064-A, 6-84 (Abstract).
Chemistry Letters, pp. 1745-1748, 1987; Tokyo Institute of Technology.
British Pharmaceuticals, Photographic, pp. 6-7, vol. 9, No. 35, 8-1969.

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