Process for the synthesis of terbinafine and derivatives...

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C564S305000, C556S410000

Reexamination Certificate

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07838704

ABSTRACT:
The present invention relates to a synthetic method for terbinafine and analogues thereof using metal catalysts, preferably Ni(II) salts and/or complexes.

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Stutz et al., “Synthesis and Antifungal Activity of (E)-N-)(6,6-Dimethyl-2-Hepten-4-Ynyl)-N-Met,Hyl-1-Naphthalenemethanamine (SF 86-327) and Related Allylamine Derivatives with Enhanced Oral Activity” Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 27, No. 12, pp. 1539-1543, 1984.
Jong et al., “A New Route to the Synthesis of Terbinafine” Bulletin of the Korean Chemical Society, Korean Chemical Society, Seoul, KR, vol. 18, No. 11, pp. 1218-1220, 1997.

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