Process for the synthesis of ribonucleotide reductase inhibitors

Details Process for the synthesis of ribonucleotide reductase inhibitors Process for the synthesis of ribonucleotide reductase inhibitors

1997-05-15

1999-02-09

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546309, 546318, C07D21373, C07D21375, C07D21361, C07D21355

Patent

active

058696768

ABSTRACT:
The present invention relates to improved, efficient chemical syntheses of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP).

REFERENCES:
Hoye, et al., "Studies of Palladium-Catalyzed Cross-Coupling Reactions for Preparation of Highly Hindered Biaryls Relevant to the Korupensamine/Michellamine Problem," J. Org. Chem., vol. 61, No. 22, 1996, pp. 7940-7942.
Zhou, et al., "Synthesis of .beta.-Mono-, Tetra-, and Octasubstituted Sterically Bulky Porphyrins via Suzuki Cross Coupling," J. Org. Chem., vol. 61, No. 11, 1996, pp. 3590-3593.
Liu, et al., "Synthesis and Antitumor Activity of Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone," Journal of Medicinal Chemistry, vol. 35, No. 20, 1992, pp. 3672-3677.

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