Process for the synthesis of pergolide

Details Process for the synthesis of pergolide Process for the synthesis of pergolide

2006-03-28

2006-03-28

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S069000

Reexamination Certificate

active

07019140

ABSTRACT:
A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8βmethylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from the yield and safety standpoint. Moreover, pergolide thereby obtained is highly pure and can be conveniently transformed into pergolide mesylate

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patent: 5463060 (1995-10-01), Misner
patent: 287 962 (2001-03-01), None
patent: 0 026 671 (1981-04-01), None
patent: 0 571 202 (1993-11-01), None
patent: WO 00 44748 (2000-08-01), None

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