Process for the synthesis of penems and carbapenems

Details Process for the synthesis of penems and carbapenems Process for the synthesis of penems and carbapenems

1981-02-02

1982-08-31

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602453, 424270, 260239A, C07D49904

Patent

active

043471838

ABSTRACT:
Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, followed by reaction of the thereby formed 1-imido-4-substituted-azetidine-2-one with a trialkyl phosphite.
Also described are novel penems useful as antibacterials which are prepared by the described process.

REFERENCES:
patent: 4172899 (1979-10-01), Christensen et al.
patent: 4203902 (1980-05-01), Shih
patent: 4206219 (1980-06-01), Christensen et al.
patent: 4269771 (1981-05-01), Lombardi et al.
patent: 4293599 (1981-10-01), Christensen et al.
Gostelli et al., Jacs 100 8214(1978).

Affiliated with

Also associated with

Rating

Process for the synthesis of penems and carbapenems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of penems and carbapenems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of penems and carbapenems will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2183880