Process for the synthesis of optically active anthracyclines

Details Process for the synthesis of optically active anthracyclines Process for the synthesis of optically active anthracyclines

2005-07-26

2005-07-26

Peselev, Elli (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S308000, C536S006400, C536S018500

Reexamination Certificate

active

06921841

ABSTRACT:
It is described a process for the synthesis of optically active anthracyclines by the fact that the key intermediate (R)2-acetyl-2-hydroxy-1,2,3,4-tetrahydronaphtalene 5,8-dialkoxy-3,4-dihydronaphtalene by acylation asymmetric dihydroxylation, transformation into chloroacetate, dehydrochloridation and final hydrolysis.

REFERENCES:
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