Process for the synthesis of oligonucleotides and analogs with l

Details Process for the synthesis of oligonucleotides and analogs with l Process for the synthesis of oligonucleotides and analogs with l

1994-06-15

1998-03-10

Hollinden, Gary E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, C07H 2100, C07H 2104

Patent

active

057263000

ABSTRACT:
Methods of synthesizing oligomers using low water oxidizer reagents which result in high coupling efficiencies are provided. These methods are suitable for larger scale preparations of methylphosphonate oligomers.

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patent: 4923901 (1990-05-01), Koster et al.
Beaucage et al., "Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach," Tetrahedron, 48(12), 2223-2311 (1992).
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Ogilvie et al., "The Synthesis of Phosphite Analogues of Ribonucleotides," Tetrahedron Letters, 21, 4145-4148 (1980).
Fourrey et al., "Improved Procedure for the Preparation of Deoxynucleoside Phosphoramidites: Arylphosphoramidites as New Convenient Intermediates for Oligonucleotide Synthesis," Tetrahedron Letters, 25(40), 4511-4514 (1984).
Windholz et al. (eds.), The Merck Index, 9th Ed., Merck & Co., Rahway, NJ, 1976, pp. 661-662 only.
Hogrefe, "Oligonucleotide Trihaloethyl Phsophotriesters: Assignment of Configureation and Utilization in Syntheses via the Phosphordichloridite Scaverngin Approach," Ph.D. Thesis, Northwestern University, Evanston, Illinois, Jun. 1987, Abstract, and pp. 80 and 87-88 only.
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Sarin et al., "Inhibition of Acquired Immunodeficiency Syndrome Virus by Oligodeoxynucleoside Methyl Phosphonates," Proc. Nat. Acad. Sci. USA, 85(20), 7448-7451 (1988).
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