Process for the synthesis of O,O-dimethyl phosphoroamidothioate

Details Process for the synthesis of O,O-dimethyl phosphoroamidothioate Process for the synthesis of O,O-dimethyl phosphoroamidothioate

1998-09-16

2000-10-03

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558199, C07F 924

Patent

active

061275662

ABSTRACT:
The present invention provides a continuous process for making O,O-dimethyl phosphoroamidothioate. In accordance with this process, O,O-dimethyl phosphorochloridothioate is reacted with ammonia and sodium hydroxide; addition of the sodium hydroxide controls the pH of the reaction mixture. The formed reaction mixture contains an aqueous phase and an organic phase. The organic phase of the reaction mixture is separated from the aqueous phase; a second organic phase is solvent extracted from the aqueous phase; and the resultant O,O-dimethyl phosphoroamidothioate is isolated from the combined organic phases via vacuum solvent stripping. In an embodiment of the present invention, the reaction of O,O-dimethyl phosphorochloridothioate with ammonia and sodium hydroxide is carried out in the presence of a solvent.

REFERENCES:
patent: 3309266 (1967-03-01), Magee
patent: 3639547 (1972-02-01), Magee
patent: 3978173 (1976-08-01), Kohn et al.
patent: 4001353 (1977-01-01), Hofer
Patent Abstracts of Japan, Japanese Patent Office, 1998, JP 10-007,691A.

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