Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulos

Details Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulos Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulos

1996-10-07

1999-02-02

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 89, 435 90, 435101, 435174, 435175, 435180, 536 221, 536124, C12P 1902, C12P 1930, C12P 1904, C12N 1118

Patent

active

058663789

ABSTRACT:
The present invention relates to processes for the enzymatic synthesis of nucleotide-6-deoxy-D-xylo-4-hexuloses starting from a nucleoside monophosphate (NMP). These processes comprise simultaneous incubation of the following substances in a buffer solution:

REFERENCES:
patent: 4039382 (1977-08-01), Thang et al.
A. Zervosen et al. "Combined Enzymatic Synthesis of Nucleotide (Deoxy) Sugars from Sucrose and nucleoside Monophosphates," Tetrahedron, vol. 52, No. 7, pp. 2395-2404, 1996.
L. Elling, "Effect of Metal Ions on Sucrose Synthase from Rice Grains--A Study on Enzyme Inhibition and Enzyme Topography", Glycobiology, vol. 5, No. 2, (1995), pp. 201-206.
L. Elling et al., "Investigation of Sucrose Synthase from Rice for the Synthesis of Various Nucleotide Sugars and Saccharides", Glycobiology, vol. 3, No. 4, (1993), pp. 349-355.
L. Elling et al., "Purification of Sucrose Synthase from Rice and its Protein-Chemical Characterization", Journal of Biotechnology, vol. 29, (1993), pp. 277-286.
C. H. Wong et al., "Regeneration of Sugar Nucleotide for Enzymatic Oligosaccharide Synthesis: Use of Gal-1-Phosphate Uridyltransferase in the Regeneration of UDP-Galactose, UDP-2-Deoxygalactose, and UDP-Galactosamine", J. Org. Chem., vol. 57, (1992), pp. 4343-4344.
K. Marumo et al., "Enzymatic Synthesis and Isolation of Thymidine Diphosphate-6-deoxy-D-xylo-4-hexulose and Thymidine Diphosphate-L-Rhamnose",Eur. J. Biochem., vol. 204, (1992), pp. 539-545.
A. Melo et al., "The Nucleotide Specificity and Feedback Control of Thymidine Diphosphate D-Glucose Pyrophosphorylase", J. Bio. Chem., vol. 240, (1965), pp. 398-405.
C. H. Wong et al., "Enzyme-Catalyzed Synthesis of N-Acetyllactosamine with in Situ Regeneration of Uridine 5-Diphosphate Glucose and Uridine 5-Diphosphate Glactose", J. Org. Chem., vol. 47, (1982), pp. 5416-5418.
J. E. Heidlas et al., "Nucleoside Phosphate Sugars: Synthesis on Practical Scales for Use as Reagents in the Enzymatic Preparation of Oligosaccharides and Glycoconjugates", Acc. Chem. Res, vol. 25, (1992), pp. 307-314.
C. H. Wong et al., "Probing the Acceptor Specificity of .beta.-1,4-Galactosyltransferase for the Development of Enzymatic Synthesis of Novel Oligosaccharides", J. Am. Chem. Soc., vol. 113, (1991), pp. 8137-8145.
Y. Ichikawa et al., "Chemical-Enzymatic Synthesis and Conformational Analysis of Sialyl Lewis X and Derivatives", J. Am. Chem. Soc., vol. 114, (1992), pp. 9283-9298.
S. A. DeFrees et al., "Ligand Recognition by E-Selectin: Synthesis, Inhibitory Acitivity, and Conformational Analysis of Bivalent Sialyl Lewis X Analogs", J. Am. Chem. Soc., vol. 117, pp. 66-79.
H. Zarkowsky et al., "The Mechanism of 6-Deoxyhexose Synthesis", J. Bio. Chem., vol. 244, No. 17 (Sep. 1969), pp. 4750-4756.
S. Chang et al., "An Epimerase-Reductase in L-Fucose Synthesis", J. Bio. Chem., vol. 261, No. 1 (Feb. 1988), pp. 1693-1697.
A. Zervosen et al., "Kontinuierliche Enzymatische Synthese von 2'-Desoxythymidin-5'-(.alpha.-D-Glucopyroanosyl)-diphosphat", Agnew. Chem., vol. 106, (1994), pp. 592-593.

Affiliated with

Also associated with

Rating

Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulos does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulos, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulos will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1116423