Process for the synthesis of nabumetone

Details Process for the synthesis of nabumetone Process for the synthesis of nabumetone

1997-01-23

1998-05-12

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568314, 568324, C07C 4565

Patent

active

057507937

ABSTRACT:
New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.

REFERENCES:
patent: 2544562 (1951-03-01), Michael
patent: 4061779 (1977-12-01), Lake et al.
patent: 5344992 (1994-09-01), Drewes et al.
patent: 5545762 (1996-08-01), Muhr
Beecham Group, Chemical Abstracts of Dutch patent 87 00,353, vol. 108, No. 204,339a, 1987.

Affiliated with

Also associated with

Rating

Process for the synthesis of nabumetone does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of nabumetone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of nabumetone will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-981229