Process for the synthesis of Losartan potassium

Details Process for the synthesis of Losartan potassium Process for the synthesis of Losartan potassium

2008-03-18

2008-03-18

Solola, Taofiq (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S252000

Reexamination Certificate

active

10913121

ABSTRACT:
Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of Losartan potassium by use of alkali metal salt such as Potassium carbonate is disclosed. A process for preparation of the polymorphic Form I of Losartan potassium is also disclosed herein.

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Burrell, Drug Safety, (1997), vol. 16(1), pp. 56-65.

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