Process for the synthesis of isosorbide mononitrates

Details Process for the synthesis of isosorbide mononitrates Process for the synthesis of isosorbide mononitrates

1982-02-16

1983-04-26

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49304

Patent

active

043814000

ABSTRACT:
The invention relates to the synthesis of isosorbide mononitrates.
The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.

REFERENCES:
patent: 3886186 (1975-05-01), Dvonch et al.

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