Process for the synthesis of indanylamine or aminotetralin...

Details Process for the synthesis of indanylamine or aminotetralin... Process for the synthesis of indanylamine or aminotetralin...

2007-08-28

2007-08-28

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S221000, C564S222000, C564S305000, C560S129000

Reexamination Certificate

active

11221035

ABSTRACT:
A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is described. The process is commercially feasible providing indanylamine and aminotetralin derivatives in high yield that are useful as intermediates in the production of therapeutically active compounds. Also described are novel intermediates, 1-indanone O-acetyl oximes and 1-tetralone O-acetyl oximes.

REFERENCES:
patent: WO98/27055 (1998-06-01), None
patent: WO 00/38673 (2000-07-01), None
patent: WO 2005/063687 (2005-07-01), None
patent: WO 2005/082838 (2005-09-01), None
Anilkumar et al, Tetrahedron Letters(41), 2000, 5427-5429.
Sterling et al, J. Med.Chem. 2002, 45, 5260-6279.
Gan, P. et al., “Synthesis of Indanones and Tetralones as New Potential Schistosomicidals,”Acta Pharmaceutica Sinica,vol. 20, No. 5, pp. 345-352 (1985) (English language abstract is on p. 352).
Oshiro et al., J. Med. Chem. 1991, 34, 2004-2013, “Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydrozyindan Derivatives” © American Chemical Society.
March's Advanced Organic Chemistry; Michael B. Smith & Jerry March, 5th Edition, chapter 10, section 10-11, 2001
March's Advanced Organic Chemistry; Michael B. Smith & Jerry March, 5th Edition p. 1194, 2001.

Affiliated with

Also associated with

Rating

Process for the synthesis of indanylamine or aminotetralin... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of indanylamine or aminotetralin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of indanylamine or aminotetralin... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3889744