Process for the synthesis of glycosaminoglycans with heparin or

Details Process for the synthesis of glycosaminoglycans with heparin or Process for the synthesis of glycosaminoglycans with heparin or

1994-03-07

1995-04-11

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 8, 514 56, 536124, 530322, 530345, C08B 3710

Patent

active

054059496

ABSTRACT:
A process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the .alpha.-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic group, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.

REFERENCES:
patent: 4987223 (1991-01-01), Choay et al.
patent: 5010063 (1991-04-01), Piani et al.
patent: 5104860 (1992-04-01), Piani et al.
Gallagher J. T., Walker A. Molecular distinctions between heparan sulphate and heparin. Analysis of sulphation patterns indicates that heparan sulphate and heparin are separate families of N-sulphated polysaccharides. Biochem. J. 1985:230:665-74.
Turnbull, J. E., Gallagher J. T. Distribution of iduronate 2-sulphate residues in heparan sulphate. Evidence for an ordered polymeric structure. Biochem. J. 1991:273:553-559.
Lindahl U., Kjellen L. Heparin or Heparan Sulfate-What is the Difference? Thrombosis and Haemostasis-F. K. Schattauer Verlagsgesellschaft mbH (Stuttgart) 66 (1)44-36 (1991).
Jaseja et al. Can. J. Chem. 1989, 67, 1449-1456.

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